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55be9034d4 These observations strongly suggest that Pax6 specifically affects these three genes among the different genes coding for transcription factors previously shown to be involved in cell differentiation and function. In addition, NeuroD1/Beta2, Isl1, MafB, cMaf, Foxa1, and Foxa2 have been proposed to regulate Glucagon gene expression in glucagon-producing cell lines (15, 24,,27). Functionally, MafB- or cMaf-deficient mice show an important reduction in both insulin- and glucagon-positive cells throughout development indicating a significant role of MafB and cMaf in differentiation, replication, and/or survival of endocrine precursor cells (17, 20). Chem. 29, 12281237 Abstract/FREE Full Text 50.
Abramson RD, Dever TE, Merrick WC (1988) Biochemical evidence supporting a mechanism for cap-independent and internal initiation of eukaryotic mRNA. Oncogene 26: 59735990. (H) Nuclear extracts of the indicated tumor cell lines (5106 cells) were analysed for the p65 binding to the NF-B double-stranded oligonucleotide, using the NF-B Transcription Factor ELISA assay kit (Cayman). J Biol Chem 274: 3541535424. DiscussionGene expression and translation regulation must be coupled in order to make available specific proteins in response to signalling. Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, et al. Materials and Methods Plasmids, Cell Transfection and Treatments Plasmids pRc/CMV, pRc/CMV-HA-p65, pRc/CMV-p50 and pRc/CMV-HA-IB- were previously described . View larger version: In this window In a new window Download as PowerPoint Slide FIGURE 2. Altogether these results indicated that the transcriptional activation of eIF4H by TNF- was mediated by p65/NF-B; these findings were consistent with eIF4H transcriptional activation by transfected p65, and eIF4H down-regulation by p65 RNA interference (Figure 1A, B).